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Gualtieri C, Johnson L

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5-Amino-1-methylquinolinium (5-Amino-1MQ) is a small-molecule membrane-permeable inhibitor of nicotinamide N-methyltransferase (NNMT) — an enzyme highly expressed in adipose tissue and liver that consumes SAM (S-adenosylmethionine) to methylate nicotinamide, simultaneously depleting methyl donor pools and reducing NAD+ precursor availability in a manner that promotes adipogenesis and metabolic dysfunction